The Crossroads Guitar Festival is a series of music festivals and benefit concerts founded by Eric Clapton. The festivals benefit the Crossroads Centre founded by Eric Clapton, a drug treatment center in Antigua. The concerts showcase a variety of guitarists, selected by Eric Clapton personally. To the 2007 audience, Clapton declared that each performer was one of the very best, and had earned his personal respect.

The first concert was held on June 30, 1999, at Madison Square Garden in New York City, and there again in 2013. The 2004 concert was held at the Cotton Bowl in Dallas, while the 2007 and 2010 festivals were held at Toyota Park, Bridgeview, Illinois, just outside Chicago. The festival returned to Dallas in 2019 at the American Airlines Center.